{"version":"1.0","provider_name":"VRIIC","provider_url":"https:\/\/vriic.usach.cl","author_name":"Comunicaciones VRIIC","author_url":"https:\/\/vriic.usach.cl\/index.php\/author\/adminvridei\/","title":"Laboratory of Neurobiology - VRIIC","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"YmbgM7ZG6q\"><a href=\"https:\/\/vriic.usach.cl\/index.php\/laboratory-of-neurobiology\/\">Laboratory of Neurobiology<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/vriic.usach.cl\/index.php\/laboratory-of-neurobiology\/embed\/#?secret=YmbgM7ZG6q\" width=\"600\" height=\"338\" title=\"&#8220;Laboratory of Neurobiology&#8221; &#8212; VRIIC\" data-secret=\"YmbgM7ZG6q\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/vriic.usach.cl\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","thumbnail_url":"http:\/\/vriic.usach.cl\/wp-content\/uploads\/2024\/09\/DSC_5407-scaled.jpg","thumbnail_width":2560,"thumbnail_height":1707,"description":"Laboratory of Neurobiology Faculty of Chemistry and Biology \/ Department of Biology DESCRIPTION The Laboratory of Neurobiology studies changes in the central nervous system and has developed new models of chronic pain compatible with the new standards of current bioethics. Research is always focused on the development of new therapies to alleviate patients with chronic pain. Some of the contributions of the Laboratory include the novel description of the Pannexin-1 channel as critical for the perception of chronic pain; and the demonstration that the BDNF neurotransmitter is one of the factors that initiates neural changes that generate chronic pain. Regarding treatments, our research team has developed and patented various polymeric nanoparticles charged with bioactive molecules capable of inhibiting pain perception for several days with a single application. SERVICES Molecule effectiveness testing in different pathology models (pain, addiction, motor alterations) Detection of antigens in biological tissues through immunehistochemical and immunofluorescence techniques RESEARCH LINE Chronic pain neurobiology Development of polymeric nanoparticles with painkilling and agroindustrial applications Development and synthesis of polymeric nanoparticles EQUIPMENT Cryostat Microtome Fluorescence microscope Electrophysiology equipment Behavioral testing equipment STAFF Luis ConstandilDirector of laboratory Alejandro Hern\u00e1ndezTenured professor Jeffri RetamalAssociated researcher Yaquelin Gonz\u00e1lezLaboratory administrator Nicol\u00e1s OnetoResearch assistant Natalia JuicaPhD in Biology candidate Mar\u00eda TrioloPhD in Neuroscience candidate CONTACT INFORMATION Contact:luis.constandil@usach.cl &#8211; laboratorio.neurobiolog\u00eda@gmail.comPhone:\u00a0+56227181092Location: Outer wing of the Faculty of Chemistry and Biology ADDRESSCasa Central, Primer pisoAv. Libertador Bernardo O&#8217;Higgins 3363, Estaci\u00f3n Central, Santiago de Chile. TELEPHONE(+56-2) 271 80047 E-MAILcomunicaciones.vriic@usach.cl Linkedin Twitter Facebook Instagram Youtube"}